Mechanisms of nickel carcinogenesis.

Molecular mechanisms of nickel carcinogenesis.

Nickel treatment of intact cultured cells oxidized dichlorofluorescin to a fluorescent product indicating that nickel elevated the level of oxidants in cells. Nickel also caused an increase in crosslinking of amino acids to DNA and these complexes did not appear to involve the direct participation of Ni2+. Histidine, cysteine and tyrosine were prominent among the amino acids crosslinked to DNA....

Recent research on nickel carcinogenesis.

Research on nickel carcinogenesis from 1975 to March 1980 is reviewed. Epidemiological studies have strengthened the evidence that workers in nickel refineries have increased risks of cancers of the nasal cavities and lungs. Clinical investigations have resulted in improved diagnosis, classification, and management of cancers of respiratory organs in nickel refinery workers. Carcinogenicity tes...

Carcinogenesis. Mechanisms of Action

The book represents the written minutes of the symposium on "Regulation of Cell Metabolism" held in London on July 28-30, 1958, sponsored by the Ciba Foundation. There is no problem of greater importance to the basic understanding of biology than the study of the autoregulatory mechanisms of the cell. The participants in this conference are all leaders in the field of biochemistry and the discu...

Mechanisms of Carcinogenesis

The role of nickel and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis.

Increasing evidence demonstrates the reactive oxygen species (ROS) are implicated in metal carcinogenesis. Exposure of cultured Chinese hamster ovary (CHO) cells to several nickel compounds, i.e. NiS, Ni3S2, NiO (black and green), and NiCl2 has been shown to increase oxidation of 2',7-dichlorofluorescein to the fluorescent 2',7-dichlorofluorescein (DCF), suggesting that nickel compounds increas...